血小板衍化生长因子受体磷酸化作用抑制剂的定量构效关系研究   总被引：2，自引：0，他引：2  

申民玉  石伟民 《洛阳师范学院学报》2006,25(5):82-84

血小板衍化生长因子受体磷酸化作用的抑制剂是治疗增殖紊乱的一类重要药物,本文采用粒子群优化训练神经网络算法对血小板衍化生长因子受体的磷酸化作用的抑制剂进行了定量构效关系研究,对其抑制活性建立了满意的预测模型.  相似文献   

黄体生成素和绒毛膜促性腺激素受体的结构和功能     

李宇 《内江师范学院学报》2001,16(4):33-36

本文介绍黄体生成素和绒毛膜促性腺激素（hCG）受体的结构和功能的研究进展。  相似文献   

X25165与AT89C51在智能监控系统中的应用     

龚德良 《衡阳师范学院学报》2001,22(6):50-53

从X25165芯片的结构、性能、工作原理出发，研究了X25165与AT89C51组成的智能监控系统的结构特点和工作原理。  相似文献   

中国汉族人群中肾上腺素α2A受体基因多态性与右美托咪定心血管效应的相关性研究（英文）     

Shao-jun ZHU  Kui-rong WANG  Xiong-xin ZHANG  Sheng-mei ZHU 《Journal of Zhejiang University. Science. B》2019,(7):598-604

目的:通过对右美托咪定静脉输注的临床研究,评价中国汉族人群中肾上腺素α2A受体基因多态性与右美托咪定心血管效应的相关性.创新点:探索右美托咪定的心血管系统反应与肾上腺素α2A受体基因多态性的关系,期望为临床个体化应用右美托咪定及其他α2受体激动剂提供重要的依据.方法:本研究取得单位伦理委员会的批准,所有受试者告知受试内容并签署知情同意书.60例美国麻醉医师协会Ⅰ-Ⅱ行择期手术汉族患者根据标准入选本研究.通过静脉输注右美托咪定,记录收缩压、舒张压、心率等心血管效应数据,并用聚合酶链式反应(PCR)法检测ADRA2A基因单核苷酸多态性.结论:中国汉族人群中肾上腺素α2A受体C-1291G基因多态性与应用右美托咪定后心率变化有相关性.  相似文献   

The diagnostic significance of the detection of cytokeratin 19 mRNA by quantitative RT-PCR in benign and malignant pleural effusions     

徐峰  陈杰  沈华浩  王选锭  单江 《Journal of Zhejiang University. Science. B》2004,(10)

  相似文献   

生物控制论在人体功能调节中的作用     

张海潮 《山西师大体育学院学报》1995,(1)

生物控制论是控制论的一门应用科学,从50年代产生并逐渐发展起来。它对人体功能调节机制初步。建立了理论体系,加之,生命过程本身就是一个控制过程。本文通过具体实例阐述了生物控制论在人体功能调节中的作用,进一步扩大其应用范围,促进体系的完善和发展。  相似文献   

肥胖及相关问题的认识(综述)   总被引：3，自引：0，他引：3  

刘刚  黄玉山 《山东体育学院学报》2001,17(3):28-30

有关肥胖机制的研究很多,提出了各种假说.对相关的肥胖危害问题也进行了研究,提出了不同的观点,就其相关知识进行总结.  相似文献   

银杏叶总黄酮对人肝癌HepG2细胞凋亡的影响及其机制研究     

厉锋  杨利丽  潘智芳  耿秀芳  刘顺梅 《潍坊教育学院学报》2009,(2):116-118

目的探讨银杏叶总黄酮对体外培养的人肝癌HepG2细胞凋亡的促进作用及其分子机理。方法采用TUNEL法检测银杏叶总黄酮对HepG2细胞凋亡的影响,提取Bcl-2基因的mRNA,以RT-PCR法研究银杏叶总黄酮对Bcl-2基因表达的影响。结果银杏叶总黄酮使人HepG2细胞凋亡指数增加（P〈0．01）,且呈剂量依赖效应;Bcl-2基因mRNA水平随银杏叶总黄酮浓度升高而降低。结论银杏叶总黄酮可促进人HepG2细胞的凋亡过程,并使Bcl-2基因mRNA水平降低,从而起到抗肿瘤的治疗作用。  相似文献   

限制饮食对大鼠血清瘦素和可溶性瘦素受体影响     

汪毅  周琨  李松波  汪洋  张爱芳 《北京体育大学学报》2012,35(2):46-49

目的:探讨20%能量限制的饮食对大鼠血清瘦素及可溶性瘦素受体的影响,通过相关指标的变化主要分析20%能量限制的饮食对于肥胖的影响和作用机制。方法:21只4周龄雄性SD大鼠随机分为对照组(C组)、限食组(R组)和高脂组(H组)。C组喂养普通饲料,H组大鼠给予高脂饲料喂养,R组给予20%能量限制的饲料喂养。喂养第16周末,测定大鼠体重、身长、肥胖评定指数(Lee’s指数)、肾周脂肪、附睾脂肪,腹主动脉取血分离血清,测试血清瘦素(Leptin)和可溶性瘦素受体(sLR)。结果:H组大鼠体重、肾脏周围脂肪和附睾周围脂肪重量非常显著性高于C组,而R组的大鼠体重、肾脏周围脂肪和附睾周围脂肪重量显著性低于C组;R组和H组大鼠的Lee’s指数与C组比较均有非常显著性差异。与C组相比,R组Leptin显著降低,H组显著升高;同时R组sLR非常显著升高,H组sLR显著降低。结论:16周的高脂饮食能显著增加大鼠的体重,提高大鼠血清Lp浓度,降低血清sLR浓度,形成肥胖。16周限制20%能量摄入的饮食,能有效地降低大鼠的体重,显著降低大鼠血清Lp浓度,提高血清sLR浓度,限制了肥胖的发生。  相似文献   

Arachnoid cell involvement in the mechanism of coagulation-initiated inflammation in the subarachnoid space after subarachnoid hemorrhage     

Zhao-liang Xin  Xiao-kang Wu  Jian-rong Xu  Xi Li 《Journal of Zhejiang University. Science. B》2010,11(7):516-523

Objective: To assess if arachnoid cells have the capability to present antigen and activate T-lymphocytes after stimulation by bloody cerebrospinal fluid (CSF), and to illuminate the mechanism of coagulation-initiated inflammation in the subarachnoid space after subarachnoid hemorrhage (SAH). Methods: Arachnoid cells were cultured, characterized, and examined by immunofluorescence for the basal expression of human leukocyte antigen-DR (HLA-DR). Expression of HLA-DR, after co-culturing arachnoid cells in vitro with bloody CSF, was investigated by immunofluorescence and flow cytometry (FCM). The variation of arachnoid cells' ultrastructure was observed by transmission electron microscope (TEM). Arachnoid cells were co-cultured with peripheral blood mononuclear cells (PBMCs). The content of soluble interleukin-2 receptor (sIL-2r) in culture medium was detected by enzyme-linked immunosorbent assay (ELISA). Results: (1) Arachnoid cells were successfully cultured for many passages. The immunofluorescent staining was positive for HLA-DR in over 95% of the human arachnoid cells. The punctate HLA-DR was distributed in cytoplasm and not in the karyon. (2) After co-culturing arachnoid cells in vitro with bloody CSF, numerous particles with strong fluorescence appeared in the cytoplasm on Day 6. On Day 8, the quantity of particles and fluorescent intensity were maximal. FCM showed that the percentage of HLA-DR expressing cells was (2.5±0.4)% at the first 5 d, increasing to (60.8±3.6)% on Day 7. (3) After co-culturing arachnoid cells in vitro with bloody CSF, many lysosome and secondary lysosome particles were present in the cytoplasm. Hyperplasia of rough endoplasmic reticulum and enlarged cysts were observed, with numerous phagocytizing vesicles also observed at the edge of the arachnoid cells. (4) Arachnoid cells stimulated by bloody CSF were co-cultured in vitro with PBMCs. The content of sIL-2r in the culture medium, having been maintained at around 1.30 ng/ml during the first 3 d, had increased by Day 4. The content of sIL-2r peaked 7.53 ng/ml on Day 7 and then reduced gradually. Conclusions: (1) Basic HLA-DR expression is present in arachnoid cells. (2) After stimulation by bloody CSF, arachnoid cells have the potential to serve as antigen presenting cells (APCs) and the ability to activate T-lymphocytes, indicating that arachnoid cells are involved in the mechanism of coagulation-initiated inflammation in the subarachnoid space after SAH.  相似文献